Human c-yes-1-Related Proto-Oncogene in Clinically Normal Dogs.
نویسندگان
چکیده
منابع مشابه
Expression of the YB5.B8 antigen (c-kit proto-oncogene product) in normal human bone marrow.
The c-kit proto-oncogene product is a member of the family of growth factor receptors with intrinsic tyrosine kinase activity. In the mouse c-kit maps to the W locus, which is known to be of central importance in hematopoiesis. Monoclonal antibody (MoAb) YB5.B8, which was raised against peripheral blood blast cells from a patient with acute myeloid leukemia (AML), was recently shown to bind to ...
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The proto-oncogene c-myc may play a role in controlling the growth and division of normal cells, and abnormalities of the gene have been implicated in the genesis of a substantial variety of human tumors. To facilitate further study of these issues, we developed antisera that permit the identification and isolation of the protein encoded by the human and other mammalian versions of c-myc. We fo...
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متن کاملAmplification of the c-yes oncogene in canine mammary tumors.
Genomic DNAs of 14 mammary tumors were analyzed by Southern blot hybridization using a human c-yes-1 oncogene probe. The amplification was successful in half of the cases (7 adenocarcinomas). The degree of amplification was approximately 4-fold, and a high proportion was seen in malignant tumors. In addition, DNA polymorphism was detected in two adenocarcinomas.
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ژورنال
عنوان ژورنال: Journal of Veterinary Medical Science
سال: 1994
ISSN: 0916-7250,1347-7439
DOI: 10.1292/jvms.56.177